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that they would normally manufacture suf cient of the vitamin in their skin during the summer to last the whole year RNIs are given for babies and younger children, the elderly, and for pregnant and lactating women and these vary between 7 and 10 g/day as compared with a typical average UK intake of only 2 3 g/day Clearly anyone whose skin is not regularly exposed to summer sunlight is unlikely to obtain enough vitamin D from their diet to satisfy the level of physiological need for the vitamin indicated by these RNIs In America an RDA is set for all age groups varying from 5 g/day for most adults, up to 10 g/day for most children, elderly people and pregnant and lactating women and this rises to 15 g/day in those aged over 70 years who are not regularly exposed to sunlight.

Because the enclosing frameset and each individual frame are all discrete hTML pages, each keeps track of its own edits and other changes. Therefore, each has its own undo memory. If you are in a particular frame and try to undo a frameset alteration, such as adding a new frame to the set, it won t work. To reverse an edit to the frameset, you have to select the frameset and choose edit Undo, or use one of the keyboard shortcuts (Ctrl+Z or Command+Z). To reverse the creation of a frameset, you must select Undo twice.

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These dietary standards are thus an implicit recommendation for the widespread use of vitamin D-containing supplements or forti ed foods Vitamin D is found naturally only in foods of animal origin and has a similar distribution to retinol (found in egg yolk, dairy fat, liver and other offal, oily sh and sh liver oil) Some other foods are forti ed with added vitamin D such as some breakfast cereals, some processed milks, infant foods and margarine Vitamin D2 (calciferol) is an alternative form of vitamin D that is formed when a fungal steroid called ergosterol is irradiated with ultraviolet light Irradiated yeast has been a convenient source of vitamin D for therapeutic use and for use in food forti cation In order to become physiologically active within the body, vitamin D must undergo two hydroxylation reactions (addition of hydroxyl or OH groups).

First, a hydroxyl group is added to carbon 25 in the liver and a second hydroxyl added at carbon 1 in the kidney to give 25-hydroxy vitamin D and 1,25-dihydroxy vitamin D respectively The 25-hydroxy vitamin D is the main circulating form of the vitamin and measures of its level in blood are used as a biochemical indicator of vitamin D status The 1,25-dihydroxy vitamin D is also called calcitriol and it behaves like a steroid hormone It could be said that the function of vitamin D is to act as a precursor to enable the kidney to synthesise this hormone The primary function of calcitriol and thus of vitamin D is to induce the synthesis of proteins in the gut that are essential for the ef cient absorption of calcium and thus the maintenance of the body s calcium homeostasis.

It is also necessary for the ef cient re-absorption of ltered calcium in the kidney Calcitriol induces key proteins that are found in bone matrix and is necessary for normal bone development, mineralisation and re-modelling Calcitriol also stimulates bone resorption by osteoclasts As some cells that are not obviously involved in calcium homeostasis have calcitriol receptors, including lymphocytes and skin cells, it is suggested that it may play a role in controlling cell proliferation and differentiation in several tissues and also in regulating immune responses Acute vitamin D de ciency leads to a condition known as rickets in children and osteomalacia in adults At the start of the twentieth century, rickets was prevalent amongst poor children living in industrial towns of Britain and other parts of northern Europe.

in which TL is the load torque and J is the motor inertia and since the electromagnetic torque can be assumed to vary approximately as the winding current, i:

Reduced calcium absorption leads to low blood levels of calcium and thus to reduced bone calci cation ultimately leading to skeletal abnormalities such as bowing of the legs and overgrowth of cartilage in the wrist and ribs Muscle weakness and high prevalence of infections are also seen in children with rickets It is also suggested that prolonged vitamin D de ciency and the compensatory increase in parathyroid hormone which releases calcium from bone to maintain blood levels may be a possible aetiological factor in the genesis of osteoporosis (brittle bones) in elderly people.

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