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Upon bacterial infection, all viral genes including the SASP were expressed The / -type SASPs are toxic to the bacterial cell since they bind bacterial DNA irreversibly, stopping all cellular activity The phage does not multiply within the target bacteria but has been shown to produce rapid killing The mechanism of action of this system provides limited opportunities for the emergence of resistance, and it is currently being developed to target the Gram-positive pathogens methicillin-resistant S aureus (MRSA) and Clostridium dif cile (Hanlon 2007) 21 Production of Non-lytic Phage Mutants One of the side effects of many antibiotics and lytic phage-based phage therapy is the release of the lipopolysaccharide of Gram-negative bacteria, which mediate the general pathological aspects of septicemia To address this issue, Hagens and Bl si (2003) evaluated the ability of a lamentous phage encoding lethal proteins to kill bacteria without host cell lysis. .net pdf 417 PDF - 417 C# Control - PDF - 417 barcode generator with free C# ...
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